Case Report Suppression of Symptoms of Alcohol Dependence and Craving Using High-dose Baclofen
نویسنده
چکیده
Aims: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. Methods: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day.Results: The patient reported dramatic reduction in cravings for and preoccupation with alcohol. Conclusions: High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.
منابع مشابه
Case Report Complete and Prolonged Suppression of Symptoms and Consequences of Alcohol-dependence Using High-dose Baclofen: a Self-case Report of a Physician
Aims: To test whether the dose-dependent motivation-suppressing effect of baclofen in animals could be transposed to humans, and suppress craving and sustain abstinence. Methods: Neurologists safely use up to 300 mg/day (10 times the dosage currently used for alcohol dependence) of high-dose oral baclofen, to control spasticity, in order to avoid invasive therapy. I am a physician with alcohol ...
متن کاملComplete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician.
AIMS To test whether the dose-dependent motivation-suppressing effect of baclofen in animals could be transposed to humans, and suppress craving and sustain abstinence. METHODS Neurologists safely use up to 300 mg/day (10 times the dosage currently used for alcohol dependence) of high-dose oral baclofen, to control spasticity, in order to avoid invasive therapy. I am a physician with alcohol ...
متن کاملSuppression of symptoms of alcohol dependence and craving using high-dose baclofen.
AIMS To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. METHODS A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day. RESULTS The patient reported dramatic reduction in cravings for and preoccupation with alcohol. ...
متن کاملLETTER TO THE EDITOR Response to Ameisen
We thank Dr Ameisen for his interest on our manuscript (Addolorato et al., 2011) and appreciate the opportunity to respond to his comments. As noted by Dr Ameisen (Ameisen, 2011), in our manuscript, we refer not only to his case report (Ameisen, 2005), but also to the case report by Bucknam (2007). We appreciate Dr Ameisen’s clarification that in his own case report high-dose baclofen suppresse...
متن کاملBaclofen-induced Psychosis in a Patient with Alcohol Dependence.
Baclofen became popular when cardiologist Olivier Ameisen described complete and prolonged suppression of symptoms and consequences of alcohol-dependence upon the use of high-dose baclofen in a self-case report (Ameisen 2005). In 2012, baclofen was approved by the AFSSAPS (Agence française de sécurité sanitaire des produits de santé French Agency for the Safety of Health Products) for use in th...
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